Thanks to our amazing ICU team for presenting the case of a 74M with chronic struvite stones who became hypotensive after stone retrieval found to have candidemia.
1. In an acute inflammatory state such as sepsis, the development of leukopenia is often due to neutrophilic tissue migration. The thrombocytopenia that often develops in these cases may be to entrapment by NETs = neutrophil extracellular traps.
2. Like staph aureus – candida is the blood is never a contaminant.
3. Given the rise of azole-resistant candida, empiric therapy for candidemia is an echinocandin – see more below.
Approach to Candidemia