Happy pre-thanksgiving day, for report this morning we went through a case presented to LT on his travels in Japan. A 83 year old gentleman with type 2 diabetes on sitagliptin and metformin develops symptoms c/f PMR, then develops an oligoarticular arthritis, all felt to be c/w DPP4-induced arthritis, which in Japan is a not uncommonly encountered side effect of the -gliptin drugs as many patients are put on these drugs as a second-line agent for type 2 DM.
The hallmark is a seronegative arthritis and symptoms of joint pain and/or muscle pain. Obviously rule out other causes (RA, PMR/GCA etc.) but remember to run the med list.
Some PMR pearls:
#PMR is usually exquisitely sensitive to low doses (10-20mg) of prednisone. IF not responding completely or minimally responsive, atypical PMR can be a paraneoplastic syndrome, look for an underlying malignancy (lung being common)