VA Report: Carbamazepine, HLA-B*1502, and SJS/TEN!

Pearl:
1) There is a strong association between the presence of HLA-B1502 and carbamazepine-induced SJS/TEN in Han-Chinese, Thai, and Malaysian populations.  

2) The FDA has recommended screening patients of Asian ancestry for the HLA-B1502 allele before starting carbamazepine.

3) Overall, carbamazepine is the most common cause of SJS-TEN!

Tangamornsuksan et al. Relationship between the HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson Syndrome and toxic epidermal necrolysis. JAMA Dermatology. 2013;149(9):1025-1032.

 

Also, take a look at this figure for a great DDx of short-lasting headaches!

Short lasting HAMatharu MS, Goadsby PJ. Trigeminal autonomic cephalgias. J Neurol Neurosurg Psychiatry. 2002;72(Suppl II):ii19-ii26.

Evernote Link!

 

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s