- In a study of 135 patients with DKA, 24% were found to have nonspecific lipase elevation defined as an elevated lipase and CT scan without pancreatitis. 8% had lipase elevations >3x the upper limit of normal. In multiple regression analyses there was a correlation with serum osmolality.
- Chorea, hemichorea-hemiballismus and severe partial seizures may be the presenting features of nonketotic hyperglycemia in type 2 diabetes
- Does this patient have cirrhosis? (from the JAMA rational clinical exam series)
- Increased likelihood: history of diabetes, ascites on exam, platelet count <160
- Lower likelihood: absence of hepatomegaly, platelet count >160
Yadav D., Nair S, Norkus EP, Pitchumoni CS. Nonspecific hyperamylasemia and hyperlipasemia in DKA: incidence and correlation with biochemical abnormalities. Am J Gastroenterol. 2000 Nov; 95(11): 3123-8.
Udell et al. Does This Patient with Liver Disease Have Cirrhosis? JAMA 2012 Feb; 307(8).