VA Neurology Report: Miller Fisher Syndrome and More!

Pearl 1: An intention tremor is characterized by onset/worsening of the tremor as the finger nears its target and reflects cerebellar dysfunction.

Click here for an example of intention tremor.

Pearl 2: Any cerebellar finding can be due to dysfunction of the cerebellar inflow/outflow tracts (in addition to dysfunction of the cerebellum itself).

Pearl 3: The Miller Fisher syndrome is a rare variant of Guillain-Barre Syndrome characterized by ophthalmoplegia, ataxia, and areflexia. The Miller Fisher syndrome does not present with the ascending paralysis of typical GBS. Miller Fisher syndrome can be diagnosed with

Pearl 4: GBS and Miller Fisher are clinical diagnoses, but supportive tests include LP (with albumino-cytologic dissociation) and anti-ganglioside antibodies.

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