AM Report Pearls: 5 “A” Classes of Common Drug Reactions – always take a history of these drugs!
- Anti-epileptic Drugs
AM Report Pearls: Types of Allergic Drug Reactions:
We discussed how different drugs have different timelines for when they cause reactions based on their pathophysiology. This nifty table of allergic drug reactions shows timeline, pathophys & examples!
|Type I||Immediate (minutes)||Mediated by IgE & mast cells||Urticaria within minutes to PCNs, periperative anaphylaxis to neuromuscular blockade, infusion rxns to chemo|
|Type II||Delayed (usually 5-8 days after)||Antibody-mediated cell destruction (uncommon)||Drug-induced hemolytic anemia (esp to cephalosporins, NSAIDs and quinine), drug-induced thrombocytopenia (esp to heparin), drug-induced agranulocytosis (to PTU, flecainide)|
|Type III||Delayed (at least a week)||IgG:drug immune complex deposition & complement activation||Drug-induced hypersensitivity vasculitis (PCN, Cephalosporin, sulfonamides, phenytoin, allopurinol)|
|Type IV||Delayed (sometimes days to weeks later)||T-cell mediated||Maculopapular/morbilliform eruptions, AGEP, SJS/TEN, DRESS (aka drug-induced hypersensitivity syndrome), drug fevers|